Tuesday, January 25, 2011

Lexapro aka Escitalopram

(taken from wikipedia)

Escitalopram (trade names Lexapro, Cipralex, Seroplex, Lexamil, Lexam) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment in adults with major depressive disorder, generalized anxiety disorder, social anxiety disorder , or panic disorder.

Despite the similarity of escitalopram and citalopram, preclinical as well as various clinical studies (including double-blinded studies) have shown differentiated effects of citalopram and escitalopram,[7] as well as a clinical superiority compared with a variety of other SSRIs, such as paroxetine,[8] especially in severely depressed patients. A head-to-head comparison of escitalopram with duloxetine found escitalopram to be both more tolerable and more effective.[9] Compared with venlafaxine[10] and sertraline[11], escitalopram was shown to have similar efficacy.

Escitalopram is not associated with significant weight gain. For example, 0.6 kg mean weight change after 6 months of treatment with escitalopram for depression was insignificant and similar to that with placebo (0.2 kg).[21] 1.4–1.8 kg mean weight gain was reported in 8-month trials of escitalopram for depression,[22] and generalized anxiety disorder.[23] A 52-week trial of escitalopram for the long-term treatment of depression in elderly also found insignificant 0.6 kg mean weight gain.[24] Escitalopram may help reduce weight in those treated for binge eating associated obesity.[25]

An analysis conducted by the FDA found a statistically insignificant 1.5 to 2.4-fold (depending on the statistical technique used) increase of suicidality among the adults treated with escitalopram for psychiatric indications.[26][27][28] Similarly, the UK MHRA data indicate an 80% increase of suicide-related events, not reaching statistical significance, in the escitalopram vs placebo patients.[29] The authors of a related study note the general problem with statistical approaches: due to the rarity of suicidal events in clinical trials, it is hard to draw firm conclusions with a sample smaller than two million patients.[30] A single case report described a patient developing suicidal ideation after beginning treatment with escitalopram, and suicidal ideation disappearing after stopping the treatment.[31]

After all the above......I just wanna say...... my doctor gave me this today.

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